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Average User Rating:
Clozapine, 3.67 / 5 (6 votes)

Clozapine Side Effects

Package for the 25 mg dosage of Clozapine.

Severe Side effects

  • If you experience weakness; extreme tiredness, fever, sore throat, chills, or other sings of flu or infection, or sores in your mouth, immediately inform your doctor.
  • Clozapine may cause a severe reduction in blood white cell count, a condition known as agranulocytosis, in about 1 in 100 patients who are on this medication for at least a year.
  • Patients received higher doses of clozapine are more susceptible to seizures that have occurred in 1 out of every 20 to 20 patients.
  • Symptoms of dizziness can be a sign of orthostatic hypotension, a marked decrease in blood, which may occur in 1 of 5 patients. It occurs when going from a lying or sitting position to a standing position. This reaction is most common during the first few weeks of therapy while the dose is being increased to find optimal dosage, when drug is stopped briefly, or when patients are also taking benzodiazepines such as diazepam (Valium) or other anti-psychotic drugs.
  • Clozapine may cause myocarditis, swelling of the heart muscle that may be dangerous. Inform your doctor immediately if you have extreme tiredness, difficulty breathing or fast breathing, fever chest pain; or fast, irregular, or pounding heartbeat.

Common Side effects

  • Drowsiness and tremors.
  • Increased salivation
  • Headache and fever symptoms.
  • Low blood pressure and increased heart rate.
  • In approximately 14% of patients clozapine slows intestine which leads to constipation.