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Average User Rating:
Duloxetine, 2.11 / 5 (9 votes)

Duloxetine Side Effects

packaging of the antidepressant duloxetine

Serious side effects

Duloxetine can cause severe allergic reactions, with symptoms including rashes, difficult breathing and swelling of the face. Patients should consult a physician if any of these symptoms occur.
  • signs of liver damage including jaundice, dark and bloody urine, vomit that looks like coffee grounds and clay-colored or tarry stools
  • behavioral changes such as agitation, impulsiveness, abnormal excitement, fear, restlessness/nervousness, panic attacks and thoughts of suicide
  • hallucinations, confusion, lack of coordination, memory loss, severe and unusual weakness and overactive reflexes
  • fainting and increased dizziness, irregular heartbeat and tight chest, increased or abnormal sweating, especially at night, and trouble sleeping
  • blurred vision or blindness with eye pain, red or irritated/burning eyes, ringing in the ears, difficult swallowing and increased thirst/dry mouth with breath odor and loss of taste
  • skin complications including easy bruising/bleeding, skin pain, blistering or peeling rashes, red skin, hives/welts on face or appendages and sex organs, red lesions with a purple center and ulcers in the mouth
  • seizures and tremors, shallow and difficult breathing or wheezing, and high fever
  • changes and difficulty in urination with vomiting blood and flu-like symptoms including chills, cough and sore throat
  • severe headache with severe rigid muscles and severe joint pain

Common side effects

  • stomach problems including abdominal pain and swelling, indigestion, loss of appetite, constipation, severe and persistent vomiting/nausea and diarrhea, that can all cause weight change
  • mild dizziness and headaches with trouble sleeping and drowsiness
  • overall mild body aches and muscle aches or stiffness, with some swollen joints
  • feeling of pins and needles or tingling skin, or feeling warmth in the upper body and face
  • sexual complications including decreased interest/drive, and ability/performance changes like abnormal orgasms, problem/prolongation of ejaculation and loss of ability to have or keep an erection