Fen-Phen Side Effects
The most significant side effects of Fen-phen have been heart valve damage, primary pulmonary hypertension, higher blood pressure, heart failure and death.
Warnings & Recalls for Fen-Phen
Fen-phen tablets and capsules were used for the management of obesity, hence the safety of fen-phen was under heavy scrutiny because of the effects agents such as norepinephrine can have. Taking fen-phen with other anti-obesity drugs was highly dissuaded and selective serotonin reuptake inhibitors such as paroxetine and fluvoxamine were never established. Serious regurgitant cardiac valvular disease, which affects the mitral, aortic and tricuspid valves had been reported in patients who were otherwise healthy who had taken a combination of Fen-phen or dexfenfluramine as a weight loss regimen.After years of controversy, the FDA requested Fen-phen’s withdrawal from the market in September of 1997. Years of litigation into Fen-phen has resulted in the company Wyeth setting aside $21.1 billion to cover the cost of the lawsuits.
Fen-Phen Treatment and Use
Fen-phen | fenfluramine/phentermine was a drug combination that was used as an anti-obesity treatment which utilized two anorectics. Fenfluramine was originally marketed by what is now Wyeth as Pondimin, but it was proven that it caused often fatal pulmonary hypertension and heart valve problems. Phentermine didn’t prove to have any significant side effects, however with the combination of these two drugs, it was deemed harmful to the general public. Fenfluramine acts like a serotonin releasing agent and phentermine acts as a norepinephrine, dopamine and serotonin releasing agent.
Other Names for Fen-Phen
Fenfluramine/Phentermine
Lawsuits & Legal Information for Fen-Phen
Author:
Lainee Hooks
Posted on May 14, 2012
