Warnings & Recalls for Janumet
Janumet Pancreatic Cancer
Janumet and other incretin mimetic medications have been linked to pancreatitis side effects such as pancreatic cancer. Discuss this risk with your doctor before taking Janumet.
Janumet Black Box Warning
Janumet as been assigned a
boxed warning for its ability to cause a rare, but serious, condition known as lactic acidosis. This condition may arise due to a build up of
metformin, one of the medications included in Janumet, and is more likely to occur in patients who drink alcohol, or suffer from acute heart failure, kidney disease, or liver disease. If you are taking Janumet and suspect that you may have developed lactic acidosis, stop taking this medication immediately and seek emergency medical attention.
Janumet is contraindicated in the patients who have a hypersensitivity to sitagliptin, mostly with side effects of anaphylaxis (sometimes fatal) and angioedema.
Notify your doctor about pre-existing health conditions before taking
Janumet | Sitagliptin Metformin such as
:
- Impaired renal function
- Gallstones
- A history of alcoholism
- High triglyceride levels
- Congestive heart failure
- 80 years of age or older
- Dehydration
- Liver problems
If you or loved one has suffered serious adverse side effects as a result of this drug, please do not hesitate to
contact someone who can help you.
Janumet Treatment and Use
What is Janumet?
Janumet | Sitagliptin & Metformin is a prescription drug used to treat Type 2 diabetes that contains a combination of biguanide and dipeptidyl peptidase-4 (DPP-4) inhibitor medications. This medication is also available in an extended-release pill prescription called “Janumet XR”.
How does Janumet work?
The “sitagliptin” component of Janumet is a medication that, when combined with diet, exercise, and other medications, lowers blood sugar levels of patients who suffer from Type 2 diabetes. The drug classification of sitagliptin is that of a dipeptidyl peptidase-4 (DPP-4) inhibitor which works by increasing the amount of certain natural substances that lower blood sugar, particularly after consuming food.
The “metformin” component of Janumet is used either alone or with other medications- which can include insulin– to treat Type 2 diabetes. The drug classification of metformin is that of a biguanide. This component helps to control the amount of glucose, or sugar, in a patient’s blood, and decreases the amount of sugar produced by the liver. Metformin also increases the body’s reception to insulin.
Janumet should not be used to treat Type 1 diabetes.
Janumet Dosage
The dosage of Janumet that a patient is prescribed depends on the individual’s current drug regimen. Janumet comes in two strengths, which may be adjusted in accordance to the effectiveness of the drug and the appearance of side effects:
- 50 mg sitagliptin/500 mg metformin HCL
- 50 mg sitagliptin/1000 mg metformin HCL
Janumet should be taken with food, twice daily, with the maximum daily dosage not to exceed 100 mg sitagliptin/2000 mg metformin.
If you or loved one has suffered serious adverse side effects as a result of this drug, please do not hesitate to contact someone who can help you.
Janumet Side Effects - Serious