Mitoxantrone hydrochloride Side Effects

Mitoxantrone hydrochloride Serious Side Effects

Cardiac effects such as fast, slow, or uneven heart rate
Signs of infection such as fever, chills, sore throat, flu symptoms, easy bruising or bleeding (nosebleeds, bleeding gums), loss of appetite, mouth sores, unusual weakness
Gastrointestinal side effects such as severe or ongoing nausea; diarrhea; black, bloody, or tarry stools, coughing up blood or vomit that looks like coffee grounds
Respiratory side effects such as shortness of breath, trouble breathing or chest pain or tightness
Urination changes such as urinating more or less than usual or experiencing pain or burning when you urinate;
Weight changes such as swelling, rapid weight gain
Dermatologic side effects such as skin changes where the medicine was injected

Less serious side effects of Mitoxantrone hydrochloride

mild nausea, diarrhea or constipation
heartburn or stomach pain
hair loss;
heavy menstrual bleeding or missed menstrual periods
runny nose
tiredness
depression
blue-green colored urine or a bluish color of the whites of the eyes for a few days after each dose

Warnings & Recalls for Mitoxantrone hydrochloride

Family Planning Warnings

This drug is a Pregnancy category D drug and may cause birth defects if either the male or female is taking it at the time of conception or during pregnancy. This drug is known to pass into breast milk and may be harmful to the infant. Nursing mothers should make the decision to either discontinue the drug or discontinue breastfeeding.

General Warnings

Patients are advised to notify their doctors before taking this drug if they have any of the following conditions:

An allergy to this medication or any of its ingredients
Heart problems such as heart disease, congestive heart failure or other heart issues
Low blood cell counts
Gout
Liver disease (including hepatitis)
Infections
Multiple sclerosis

Information on interactions with this drug is limited, however patients are strongly advised to notify doctors of all prescription drugs, over the counter drugs and vitamins they are on before taking mitoxantrone.

Mitoxantrone hydrochloride Treatment and Use

What is Mitoxantrone hydrochloride?

Mitoxantrone hydrochloride | Novatrone is an antineoplastic agent used in the treatment of nonlymphocytic leukemia, prostate cancer and multiple sclerosis (MS).

How does Mitoxantrone hydrochloride work?

Mitoxantrone hydrochloride works by suppressing the body’s immune system.

Mitoxantrone hydrochloride Dosage

Mitoxantrone hydrochloride is administered intravenously by medical professionals.

MS: 12 mg/m² administered as an IV infusion approximately 5 to 15 minutes every 3 months

Prostate Cancer: 12 mg/m² administered as an IV infusion every 3 weeks

Acute Nonlymphocytic Leukemia: 12 mg/m² daily on days 1-3 of initial therapy administered through an IV, along with 100 mg/m² of cytarabine given as a continuous 24-hour infusion on Days 1-7.