Fluvoxamine Side Effects

Serious side effects:

• seizures and easy bruising and bleeding
• changes in behavior like irritability/agitation, euphoria, racing thoughts
• hallucinations, confusion and loss of coordination/balance, with fainting or lightheadedness
• rigid muscles, high fever and abnormally active reflexes
• fast and uneven heart rates, shivers/tremors, with trouble concentrating and memory loss
• weakness and shallow and fleeting breathing
• suicidal thoughts or attempts, twitching muscles, worsening anxiety, trouble sleeping, impulsiveness, restlessness or hyperactivity should be reported to a physician
• black stools and vomit that looks like coffee grounds should also be reported to a physician 

 

Common side effects:

• changes in appetite that may fluctuate weight, with nausea vomiting, constipation, diarrhea and upset stomach/indigestion
• headaches and minor fever with sore throat and cough
• dizziness and weakness with drowsiness and some insomnia
• some anxiety issues and muscle pain with increased sweating and dry mouth
• sexual problems like low libido, long-lasting erections, abnormal ejaculation and trouble reaching climax
• abnormal tastes in mouth, nose bleeds, sinusitis and increased infections
• increased pain during menstruation and feelings of pins and needles on the skin

 

Warnings & Recalls for Fluvoxamine

Black Box Warning

The has mandated that a Black Box warning be added to Fluvoxamine because of the increased risk of suicidal behaviors in young adults (up to 24 years old) and children. Fluvoxamine has been found to be 8 times more likely to be associated with violence in patients than other medications.

Risks of any suicidal thoughts in all patients are increased in those with a family history of bipolar disorder or mania.

Other warnings

Patients should discuss with their doctor if the benefits of Fluvoxamine outweigh the risks of suicidal tendencies and worsening depression, especially those under the age of 25. A physician will readily test patients for at least 12 weeks after beginning Fluvoxamine.

Those who were taking Fluvoxamine for 5-36 weeks will experience withdrawal reactions after discontinuing the drug. These reactions may continue for 12-21 days, and should be relieved within 1 day of retaking Fluvoxamine.

Fluvoxamine may cause serotonin syndrome, especially mixed with particular drugs. (See contraindications)

Before beginning the medication, patients should make aware any history of bipolar or manic-depressive disorders, suicide attempts, liver problems, history of seizures, low sodium intake (electrolyte imbalance), ulcers or bleeding problems, history of blood clotting disorders, kidney disease, history of heart disease or high blood pressure or history of strokes as all may cause complications when mixed with Fluvoxamine.

Those who are allergic to Fluvoxamine or any of its ingredients (fluvoxamine maleate, carnauba wax, hydroxypropyl methylcellulose, mannitol, polyethylene glycol, polysorbate 80, pregelatinized starch, silicon dioxide, sodium stearyl fumarate, corn starch, titanium dioxide and synthetic iron oxide) should NOT take this drug.

Drinking alcohol with Fluvoxamine can increase the effects of the drug.

Patients are advised to not operate heavy machinery until they are aware of how it will affect them as it can impair thinking.

Older patients can be extra sensitive to the side effects of Fluvoxamine, like excessive bleeding. They can develop a severe mineral (electrolyte) imbalance, especially when this drug is paired with diuretics.


Contraindications:
Contraindications include diuretics, lithium, clopidogrel, methadone, omeprazole, St. John's wort, tacrine, tramadol, tryptophan, theophylline, warfarin, other antidepressants (amitriptyline, clomipramine, imipramine), heart and blood pressure medications, migraine medications, chlorpromazine, clozapine, haloperidol, perphenzine, sedatives, and seizure medications.

Alosetron, amelteon, tizanidine, thioridazine, pimozide, MAOI's (for up to 14 days before or after taking Fluvoxamine) like furazolidone, methylene blue, mocolobemide, procarbazine, linezolid, risocarboxazid, phenelzine, ragagiline, selegiline and tranylcypromine are also contraindicated.

Patients should be advised that alprazoam, trizolam, alosetron, ibuprofen, visapride, beta-blockers, terfenadine, astemizole, cisapride, methadone, melatonin, ramelteon, tacrine, dextromethorphan, sibutramine, antihistamines, muscle relaxants, sleep or anxiety drugs, narcotic pain relievers, paroxetine, duloxetine, venlafaxine, large amounts of caffeine and cigarettes all increase the risks associated with this drug.


Family Planning:
Fluvoxamine has been known to cause heart defects and lung problems to the fetus, therefore caution should be taken when this drug is administered to pregnant patients. Fluvoxamine should only be used when the patient, along with a physician, has determined that the benefits outweigh the risks associated with the drug.

Patient who become pregnant while on Fluvoxamine should not immediately stop taking the drug, but turn to their doctor for ways to slowly diminish her intake of the drug.

Infants exposed to Fluvoxamine within the last 3 months of pregnancy may develop withdrawal symptoms (abnormal crying, feeding difficulties, difficult breathing, seizures, muscle stiffness) and are at risk for persistent pulmonary hypertension- a fatal condition for newborns.

Fluvoxamine will be passed to a newborn through breast milk. Nursing mothers are advised to NOT take this drug while breast feeding.

Other Names for Fluvoxamine

Luvox^®

Luvox^® CR